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Genale reviews

In this article, you can read the instructions for use of the drug. Genale. Presented reviews of visitors to the site - consumers of this medicine, as well as the opinions of doctors, experts on the use of Genale in their practice. A big request to add your feedback on the drug more actively: the medicine helped or did not help to get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogs Zhenale in the presence of available structural analogues. Use for emergency post-coital contraception (after intercourse) in women, as well as during pregnancy and lactation. The composition of the hormonal contraceptive drug.

Genale - synthetic steroid antiprogestogen drug. It blocks the action of progesterone at the receptor level, does not possess gestagen activity. Antagonism with glucocorticosteroids (GCS) due to competition at the level of communication with receptors was noted.

Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug, desquamation of the decidual membrane and removal of the ovum occurs. It causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.

Composition

Mifepristone + excipients.

Pharmacokinetics

After a single oral administration, Cmax is reached in 1.3 hours. Absolute bioavailability is 69%. In blood plasma, mifepristone is 98% bound to proteins: albumin and acidic alpha1-glycoprotein. After the distribution phase, excretion first occurs slowly, the concentration decreases by 2 times between 12-72 h, then more quickly.

Indications

  • emergency (postcoital) contraception within 72 hours after intercourse without prior use of contraceptives or methods, as well as their unsuccessful use (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, breaking or slipping of the condom).

Forms of release

Other dosage forms, whether vaginal suppositories or solution for douching does not exist.

Instructions for use and method of use

Take 1 tablet by mouth for 2 hours before or 2 hours after meals (within the next 72 hours after unprotected intercourse), regardless of the phase of the menstrual cycle.

Side effect

  • bleeding from the genital tract,
  • discomfort and lower abdominal pain,
  • exacerbation of inflammatory diseases of the uterus and appendages,
  • nausea, vomiting,
  • diarrhea,
  • headache,
  • dizziness,
  • weakness,
  • hyperthermia,
  • hives.

Contraindications

  • acute or chronic renal and / or liver failure,
  • long-term therapy with glucocorticosteroid agents,
  • porphyria,
  • anemia,
  • disorders of hemostasis (including prior treatment with anticoagulants),
  • the presence of severe extragenital pathology,
  • adrenal insufficiency
  • pregnancy,
  • lactation period
  • history of hypersensitivity to mifepristone and / or auxiliary components.

Use during pregnancy and lactation

The drug Genale can not be used during pregnancy. Breastfeeding should be stopped for 14 days after taking the drug.

Use in children

Use in elderly patients

special instructions

The drug does not protect against sexually transmitted diseases and AIDS.

It is not recommended to use the drug as a planned, permanent contraception after each sexual intercourse, as well as monthly.

After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. With further sexual intercourse should use a barrier method of contraception.

With a delay in the prescribed cycle time of menstruation after the use of the drug Genale, it is necessary to consult a doctor to diagnose a possible pregnancy.

A dose of 10 mg is not sufficient to induce an abortion, so prior to its further use, a highly sensitive pregnancy test should be carried out to ensure that this drug is used only in the absence of pregnancy. In the event of pregnancy, despite the use of the drug, it is recommended that it be interrupted using a drug or surgical method. If the patient decides to preserve the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.

The drug is available on prescription.

Influence on ability to drive motor transport and control mechanisms

The influence of the drug on the ability to drive and work with mechanisms is not marked.

Drug interaction

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) should be avoided for 8-12 days after taking the drug.

Analogues of the drug Genale

Structural analogues of the active substance:

  • Agesta,
  • Ginepriston,
  • Ginestryl,
  • Miropriston,
  • Mifegin,
  • Mifeprex,
  • Mifepristone,
  • Mytholian,
  • Pencrofton.

Analogs for pharmacological group (contraceptives):

  • Anteovin,
  • Belara,
  • Bellune 35,
  • Benatex,
  • Bonade,
  • Gestarela,
  • Gynecotex,
  • Demoulen,
  • Jess
  • Jes plus
  • Diane 35
  • Dimia,
  • Evra,
  • Janine,
  • Genette,
  • Zoeli
  • Claira,
  • Contracetin T,
  • Laktinet,
  • Lei,
  • Lindinet 20,
  • Lindinet 30,
  • Loveston
  • Logest,
  • Marvelon,
  • Mersilon,
  • Midiana,
  • Mikroginon,
  • Microlute
  • Minisiston
  • Mirell,
  • Mirena,
  • Modelle,
  • Novara,
  • Novinet,
  • Non Avonon,
  • Norkolut,
  • Norplant
  • Ovidon,
  • Oralcon,
  • Postinor
  • Regulon,
  • Rygevidon,
  • Silest,
  • Siluet,
  • Sinfaz,
  • Sterilin
  • Three regol,
  • Trigestrel,
  • Triquilar,
  • Pharmatex,
  • Femoden,
  • Chloe,
  • Egestrenol,
  • Exluton
  • Erica 35,
  • Eskapel,
  • Eskinor F,
  • Yarin,
  • Yarina Plus.

Brief instructions for use, contraindications, composition

Indications (from what helps? What is it for?)
Zhenale is a means of emergency contraception, it must be taken within 3 days following sexual intercourse, which was not accompanied by effective methods of contraception. It can be used when an unsuccessful attempt to interrupt intercourse, either due to poor quality or lack of contraceptive.

Contraindications
Cases in which the General is not appointed:
• an increased level of sensitivity to the drug,
• renal, adrenal, hepatic failure,
• diseases of the genital organs, accompanied by inflammatory processes,
• long-term use of glucocorticoids,
• severe degree of extragenital pathology,
• porphyria,
• anemia,
• scars on the uterus.
Mandatory consultation with a doctor is required if the patient is a smoking woman over 35 years old.
There are also some restrictions on admission to Genale for the purpose of termination of pregnancy, preparation and induction of labor, and therapeutic treatment for the diagnosis of uterine leiomyoma.

Method of application (dosage)
The medication is intended for oral administration. The recommended dose is 1 tablet. You must take it 2 hours before or after meals. Genel is effective for use within 3 days after intercourse, when contraceptive measures were not followed.

Special instructions (cautions)
For termination of pregnancy with the help of wenale, the patient must be supervised by the medical staff.
With treatment, breastfeeding stops for a period of 2 weeks.

Side effects
Side effects that may occur as a result of taking Genale:
• weakness, lethargy, Headache, Dizziness,
• nausea, diarrhea, gagging,
• discomfort in the abdomen,
• hyperthermia,
• allergic skin reactions.
In some cases:
• bleeding
• pain in the abdomen,
• exacerbation of infectious diseases of the uterus and urinary organs.

Release form
Available in pill form (10 milligrams of active ingredient). In 1 blister pack there is 1 tablet. In total in a pack or in a jar there can be 1 or 2 pieces.

Recommendations / feedback from doctors: We have a large consultation section on our website, where Genale is discussed 20 times by patients and doctors.

pharmachologic effect

Most patients are interested in the question of how Genale works, as some similar pills can harm the fertility system, hormones, and the menstruation cycle.

Tablets are steroid anti-progestogenic drugs of synthetic origin, that block the interaction of progesterone and receptors.

The main task of the tablets is to increase the contractility of the myometrium, as a result of which the fetal egg is removed, the process of ovulation is slowed down, and the implantation of a fertilized cell into the uterus is complicated.

Also in the tablets "Genale" there are additional substances by type:

  1. potato starch,
  2. lactose monohydrate,
  3. povidone,
  4. magnesium stearate.

Composition and release form

The main active ingredient of the drug "Zhenale" is mefipriston, which is a synthetic steroid that increases the sensitivity of the myometrium to Pg.

Gestagens, homologues and antagonists have been added to enhance exposure.

Also included in the preparation:

Each package consists of 10 mg, may be offered in a blister strip or can.

Indications for use

There may be several indications for the use of Genale tablets, but all of them are established following the recommendations of the doctor, testing and diagnosis.

In most cases, starting a course is recommended.:

  • for termination of uterine pregnancy in the early stages, tablets of 200 mg,
  • to prepare for childbirth during normal pregnancy,
  • Dri diagnosis of uterine leiomyoma sizes up to 10 weeks,
  • for emergency contraception in the next 72 hours, if previously the means and methods of contraception were used incorrectly.

Although then the course of pills will be different, usually it is shorter and combined with other medications.

Contraindications

There are a number of contraindications when using the Genale tablets, which need to be taken into account, to do tests for personal tolerance of some components.

Usually it is about:

  • hypersensitivity
  • renal failure, intestinal diseases,
  • liver failure
  • porphyrias,
  • inflammations and infections of the female genital organs,
  • problems with hemostasis,
  • smokers and women after 40 years
  • for termination of pregnancy, for ectopic pregnancy, for delayed menstruation for more than 40 weeks,
  • uterine myoma,
  • with postponed or unfinished pregnancy,
  • ovarian tumors,
  • breastfeeding period,

The same applies to cases where the disease was found after the start of the course of taking pills.

Side effects and consequences

Almost every woman after starting a course with Genale tablets can face side effects that appear after a few hours and can last up to a week.

So the majority of patients is faced not only with delayed menstruation, bleeding after the drug, but also other troubles:

  • pain in the abdomen or during intercourse,
  • weakness
  • nausea, vomiting,
  • diarrhea, intestinal upset,
  • bleeding, vaginal discharge,
  • infections and inflammations of the urogenital system,
  • anemia, decreased hemoglobin.

Drug interaction

You should not take Genale tablets with menopause preparations, antibiotics, agents for treating epilepsy and tuberculosis.

It is also better to avoid simultaneous use with NSAIDs for the next 10 days after the introduction of mythhenpriston.

Regarding alcohol, the effectiveness of the active component of the drug "Zhenale" - does not decrease, although a woman may suffer from dizziness, nausea and spasms.

Genal and Alcohol

Doctors do not recommend combining contraceptive drugs, tablets for menopause and tuberculosis with alcohol, although there have not yet been any serious consequences after Genale.

In the presence of kidney, liver or intestinal diseases, digestion may worsen, there is a sharp weight jump, diarrhea, indigestion, vomiting and nausea.

Dosage and overdose

For an abortion, it is necessary to take 600 mg of the drug "Zhenale" in the hospital, only after a light breakfast, and drink plenty of water.

The procedure is carried out once, two hours after meals. When a woman is prepared for childbirth, you need to enter 200 mg tablets once, and a day later repeat the reception.

Further, the diagnosis is carried out by a doctor and oxytocin can be prescribed.

As a means of contraception, Genale tablets are used only after a doctor's permission in a dose of 10 mg after or before a meal, preferably within two hours.

If we are talking about unprotected sexual contact, it is recommended to take the pills within 72 hours after fertilization.

When uterine leiomyoma is detected, the Genale course of pills will last at least two to three months with 50 mg of the drug.

In other cases, with hormonal disorders or for the treatment of acne, the dosage may vary significantly, as well as the time of admission.

If we talk about overdose, the patient is faced with symptoms of renal failure, namely, high fever, abdominal pain, dizziness, swelling, pain when urinating. Treatment is applied symptomatic, depending on the tests and recommendations of the doctor.

Instructions for use

The dosage of the drug “Genale” is prescribed different, depending on the diagnosis, the purpose of treatment and the age of the patient, often the doctor controls the intake of tablets.

Most often, they drink the tablets after a light breakfast-lunch or before it in two hours, they do not need to be chewed, but it is better to drink 100 ml of water.

In most cases, patients undergo an ultrasound procedure through 30-40 hours after the first dose tablets "Genale", and then a week later.

This is done in cases of treatment of uterine leiomyoma, for termination of pregnancy or in preparation for childbirth.

How often “Genal” can only be taken by a doctor, so before starting a course, it is important to undergo a full examination.

Drug storage

Store the drug "Zhenale" need in a dry, dark place, with a temperature of not more than 25 degrees Celsius.

It is necessary to avoid direct sunlight, interaction with liquid tinctures, water.

The activity and effectiveness of the main components retain no more than three years, after which the Genale tablets must be disposed of or discarded.

Otherwise, the patient will face side effects, deterioration of health.

special instructions

It must be remembered that the course of Genale pills does not depend on the menstrual period, the woman does not protect against sexually transmitted infections and AIDS.

Despite its effectiveness, doctors recommend using the drug only in special cases, for emergency contraception or for preparing for childbirth. Monthly intake - not recommended.

Related videos:

If it was not possible to avoid pregnancy, it is necessary to come to the doctor and go through surgery.

Also, tablets can lead to fetal abnormalities, complications of pregnancy.

Analogs and Substitutes

There are also a number of analogue substitutes that have a similar effect, indications, but lower cost. We are talking about Agesta, Ginepristone, Miropristone, Postinor and Eskapel.

Photo Gallery:

Their price fluctuates at the level of 400-4000 rubles.

Useful video:

Which is better: Zhenale, Postinor or Escapel?

If we compare the main analogues of the drug “Eskapel” and “Postinor”, ​​then the “Genale” tablets have less hormones in their composition, but remain effective even on the third day after fertilization.

Also, when taking Genale, women are much less likely to experience bleeding and menstrual irregularities.

Reviews of gynecologists

Uskova Alla, gynecologist:“It is important that every woman understands that Genale tablets are not a panacea for eliminating unwanted pregnancy. It is necessary to select an appropriate contraceptive after consulting a doctor who will solve this problem every time without harm to health. ”

Bashnev Pavel, gynecologist:“You should not take Genale pills without the supervision of a general practitioner or gynecologist, as this is fraught with the appearance of severe bleeding, pain and even a death condition. Take Genale tablets only at the indicated dosage and follow-up at the hospital. ”

Women reviews

Inna, 25 years old:"I can not say about the effectiveness of the drug" Zhenale "in the contraceptive process as a matter of urgency or to interrupt early pregnancy. But as the doctors said, do it only after consulting and testing, otherwise you can seriously ruin your health. So one of my friends drank Zhenale, and her period became strange, rare. ”

Natalia, 29 years old:“I took the drug to Zhenale for preparation for childbirth, so I will highlight only the positive qualities of the pills, since I gave birth quickly, without problems, the uterus expanded in three hours, and almost did not feel pain. She was a little afraid of bleeding, complications after Genale tablets, but everything worked out. ”

Genale: composition, release form and packaging of the drug


The drug is available in the form of round yellow biconvex tablets, sometimes with a greenish tinge.

One tablet contains 10 mg of mifepristone, as well as excipients - 22 mg of potato starch, 123.4 mg of lactose monohydrate, 6 mg of povidone C25, 5 mg of carboxymethyl starch sodium and 1.6 mg of magnesium stearate.

Packed one tablet in blister packs (in a pack of 1 or 2 tablets) or in orange glass jars (1 or 2 tablets in a jar). Sold in carton packs.

Pharmacodynamics


The active ingredient of the tablets Genale - mifepristone, anti-progestogen steroid of synthetic origin, capable of blocking the interaction of progesterone and gestagen receptors.

Mifepristone in varying degrees increases the contraction of the myometrium and stimulates the release of interleukin-8 in choriodecidual cells (the degree depends on the menstrual phase), which results in desquamation (in other words, scaly desquamation of the epithelium layer) of the decidual membrane. Together with desquamation occurs and the rejection of the ovum. Also due to desquamation when taking the drug is impossible ovulation.

Pharmacokinetics

Already after 1.5 hours after taking the drug orally maximum blood concentration. The drug is bioavailable at 69-70%. 99.2% of mifepristone is bound to plasma proteins. The half-life occurs in 17 hours. Withdrawal of funds occurs in two stages, at first rather slowly, and after 12-72 hours much faster.

Genalet tablets: instructions for use

  • For emergency contraception, take one pill (10 mg) by mouth for a couple of hours before or after meals, and this should be done within 72 hours after intercourse. The phase of the menstrual cycle does not affect reception. For termination of pregnancy, the drug must be taken no later than 42 calendar days of delayed menstruation.
  • For medical termination of pregnancy at an early period in the presence of a physician, a drug is taken with a dosage of 600 mg once. It is better to do this in the morning on an empty stomach, and after 1-1.5 hours to take breakfast. On the third day after taking the pills, the patient must undergo an ultrasound control. Also after two weeks ultrasound is repeated, in the absence of the effect of mifepristone, vacuum aspiration is performed.
  • In preparation for childbirth, Genal is taken at a dosage of 200 mg in the presence of a physician and 200 mg again a day.
  • With leiomyoma, the uterus takes 50 mg per day for three months.

Genale tablets: side effects

To side effects after taking contraception can be attributed weakness, headache, discomfort in the lower abdomen, nausea and vomiting, hyperthermia, diarrhea, rash on the skin, menstrual disorders, bloody discharge.

Additionally, it is possible to note the effects associated with abortion: bleeding, inflammation of the uterus or appendages, pain in the lower abdomen, exacerbation of inflammation of the urinary tract or uterus.

Genéle: drug analogues

  • There are structural analogues, the active substance in which also mifepristone, for example, Agesta, or Ginestryl (also Ginepriston), and a number of drugs with a similar name: Miropriston, Mifeprex, Mifegin, Mifolian, etc.
  • There are also analogues in the pharmacological group. These include items such as Postinor, Benatex, Gynecotex, and others.

Most often, girls in a pharmacy have a controversial question: buy Zhenale or Postinor? To answer it, you need to compare the two drugs in more detail.

The active substance of Postinor is levonorgestrel. In fact, Postinor also refers to post-coital contraception and has a similar principle of action, the instructions for using these drugs are almost the same. Feedback on each drug can be found on the Internet. However, there is a slight difference in price. And in this case, Genale, whose price is about 250 rubles, is more profitable than Postinor with a cost of 350 rubles.

Genalet tablets: patient reviews

I have never used the method of emergency contraception, but it turned out that it was necessary to urgently accept either Genale or Postinor. Chose Zhenale. In principle, I did not feel any side effects.

Always protect yourself if you don't want to get pregnant. In an emergency situation, Genale's tablet helped me, but it is better not to bring this up.

Zhenale used to abort pregnancy on the advice of a doctor. There was bleeding, terrible pain, but still a miscarriage occurred. I think such side effects occur after any medical abortion, not necessarily with Genale.

Treated uterine leiomyoma, took a course for three months. The drug helped, but sometimes nauseous and dizzy.

Zhenale or Escapel - which is better?

Escapel refers to preparations containing progestogens (hormones). The tool, unlike the original, is effective only for the first 24-48 hours, after NPA. Also, when taking an analogue increases the likelihood ectopic pregnancy. The cost of drugs is about the same.

Postinor or Zhenale - what to choose?

Postinor also contains progestogens. The effectiveness of the remedy strongly depends on the patient's body mass (this indicator is lower in the original). After taking an analogue, there is a greater likelihood of undesirable side effects - bleeding, general malaise, delay of the next menstruation. Both funds are in the same price category.

Indications drug Genale ®

Emergency (post-coital) contraception within 72 hours after sexual intercourse without prior use of contraceptives or methods, as well as their unsuccessful use (including an error in using the calendar method, unsuccessful interruption of sexual intercourse, breaking or slipping of the condom).

Precautionary measures

The drug does not protect against sexually transmitted diseases and AIDS, it is not recommended to use the drug as a planned, permanent contraception after each sexual intercourse, as well as monthly.

After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. With further sexual intercourse should use a barrier method of contraception.

A dose of 10 mg is not sufficient to induce an abortion, so prior to its further use, a highly sensitive pregnancy test should be carried out to ensure that this drug is used only in the absence of pregnancy. In the event of pregnancy, despite the use of the drug, it is recommended that it be interrupted using a drug or surgical method. If the patient decides to preserve the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.

Influence on the ability to drive a car or perform work that requires increased speed of physical and mental reactions. The influence of the drug on the ability to drive and work with mechanisms is not marked.

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